Azelex Cream (azelaic acid) is a prescription topical medicine used to treat skin conditions like inflammatory acne and rosacea. Azelex is from a class of drugs known as topical acne agents. Azelex contains azelaic acid, a naturally occurring saturated dicarboxylic acid. Azelex works by helping the skin renew itself at a faster rate, reducing blackhead and pimple formation. Azelaic acid also contributes to killing harmful bacteria that lead to acne and rosacea.

Always refer to the drug’s packaging leaflet before applying Azelex Cream
Always follow your doctor’s instructions

• Wash your hands thoroughly before applying
• Clean the affected area with a mild soap or cleansing lotion
• Pat dry with a soft towel
• Apply Azelex Cream as directed
• Apply twice daily: once in the morning and once before bed
• Do not cover the area Azelex Cream is applied to

Before taking Azelex Cream, inform your doctor if:

• You are allergic to azelaic acid
• You are allergic to propylene glycol
• You are pregnant or breastfeeding

Common side effects of Azelex Cream that require your doctor’s attention include:

• Severe burning, stinging, or warmth
• Severe redness, peeling, irritation, or dryness
• Changes in the color of your skin
• Severe itching or tingling

What other drugs will likely affect Azelex Cream?

Because Azelex Cream is applied topically, it is not likely another orally or injected drug will interact with azelaic acid. However, other topical medications or herbal products may reduce this drug’s effectiveness. Isotretinoin is known to interact with Azelex, but other medications may also cause unwanted side effects. Ask your doctor for a comprehensive list of Azelex drug interactions, and always disclose the medications you are taking before starting treatment.

What are some risks associated with applying azelaic acid?

When treating skin conditions with Azelex Cream, it is important to monitor for early signs of hypopigmentation, which involves patches of the skin becoming lighter than your overall skin tone. Some have reported hypopigmentation after the use of azelaic acid. Studies have not been done on the effect of azelaic acid on patients with darker complexions.

What should I do if I experience side effects of Azelex Cream?

Most side effects do not require urgent medical care. These include temporary stinging, flaky skin, and tingling or itching. However, if you experience severe swelling in your face, lips, tongue, or throat, or if you experience difficulty breathing, contact your doctor right away. Speak with your healthcare provider for more tips on how you should handle the side effects of Azelex Cream.