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What is Entresto?

Entresto is a medication used in the treatment of certain types of heart failure. Heart failure is characterized by the inability of the heart to pump enough blood to the rest of the body. Entresto contains sacubitril, which is a neprilysin inhibitor and valsartan, an angiotensin II receptor blocker.

These two medications work by dilating blood vessels to decrease blood pressure and reduce sodium levels. Valsartan keeps the vessels from narrowing, ensuring a healthy blood flow. This medication is generally prescribed to those with chronic heart failure.

Before beginning a new medication, you should read the information leaflet and follow your doctor’s instructions.

  • Take this prescription by mouth with or without food
  • This medication is usually taken twice a day, but make sure to follow your treatment plan
  • You may start this medication at a low dose and gradually increase over time with your doctor’s instruction
  • Use Entresto regularly to get the most benefits from this drug


Tell your doctor if you are allergic to any ingredients within Entresto. You should be cautious of the following factors when taking Entresto:

  • Do not take this drug with ACE inhibitors like captopril or enalapril
  • Do not take Entresto for at least 36 hours before or taking an ACE inhibitor

Before starting Entresto, tell your doctor if you have a medical history of:

  • Liver disease
  • Kidney disease
  • Dehydration
  • Electrolyte imbalance
  • Serious allergic reactions

This drug may make you dizzy, so consuming alcohol or marijuana may make this dizziness more severe. It may also increase your potassium levels, so talk to your doctor before using potassium supplements or salt substitutes that contain potassium.

Side Effects of Entresto

Common side effects of Entresto include:

  • Cough
  • Dizziness
  • Lightheadedness

These side effects will likely go away over time, but if the symptoms persist or worsen, talk to your doctor. Severe side effects include:

  • Fainting
  • Change in the amount of urine
  • Symptoms of high potassium (muscle weakness or irregular heartbeat)
  • Allergic reaction (trouble breathing, swelling of the face)


What happens if I miss a dose of Entresto?

Everyone makes mistakes when it comes to their treatment plan, but it is important to take a missed dose as soon as you remember. If it is near the time of your second dose for the day, skip the missed dose. Do not double dose.

How should I store Entresto?

It is essential to store your medications properly to maintain the integrity of your pills. You should keep Entresto away from light and moisture, so do not store it in the bathroom or refrigerator. Make sure you keep it in a place where animals or children cannot reach it. Do not flush medications down the toilet and talk to your pharmacist about how to properly discard unused medications.

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March 20, 2023

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February 10, 2023

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February 9, 2023

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January 23, 2023

Great prices, easy to order, very helpful in answering questions.

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December 15, 2022

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A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.
VALSARTAN: Generic drug disclaimer: This drug is not manufactured by NOVARTIS.

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