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What is Premarin Vaginal Cream (conjugated estrogens)?

Premarin Vaginal Cream is a prescription medication used to treat menopause symptoms like atrophic vaginitis, dyspareunia, burning, irritation, and vulva itching. Premarin belongs to a class of drugs known as estrogen derivatives. It can be used alone or with certain other medications. Premarin Vaginal Cream contains a mixture of estrogen, a female sex hormone essential for proper body function. Premarin is applied to the vagina and may be used for purposes not listed.

Always refer to the packaging instructions before applying Premarin Vaginal Cream
Always completely follow your healthcare provider’s instructions

  • Use only the vaginal applicator provided
  • Clean applicator with mild soap and warm water after each use; do not use hot water
  • Attend regular check-ups with your doctor to determine effectiveness of treatment
  • Monitor yourself for any lumps on your breasts
  • Have regular mammograms
  • Stop treatment with Premarin if you have an upcoming surgery or will be on bed rest


You must not use Premarin Vaginal Cream if you are pregnant. Before using Premarin as treatment, inform your doctor if you have ever had one of the following:

  • Seizure disorders
  • Porphyria
  • Endometriosis
  • Angioedema
  • A thyroid disorder
  • Kidney disease
  • Migraines
  • High levels of blood calcium
  • Lupus
  • Gallbladder disease
  • Liver disease
  • A Hysterectomy
  • Asthma
  • Heart disease

You should not use Premarin if you have:

  • A history of stroke, blood clot, or heart attack
  • An increased risk of blood clots
  • A history of hormone-related cancer, breast cancer, uterus cancer, cervix cancer, vaginal cancer
  • Unusual vaginal bleeding
  • Liver disease

Premarin Vaginal Cream can also weaken the integrity of a latex condom. Taking conjugated estrogens can increase your risk of heart attack, stroke, and blood clots, especially if you have high blood pressure, diabetes, or high cholesterol.

Side Effects of Premarin

Common side effects of Premarin Vaginal Cream include:

  • Breakthrough bleeding (spotting)
  • Vaiginal discharge, itching, or changes in your menstrual periods
  • Breast pain
  • Headache
  • Flushing, warmth, redness, or a tingly feeling
  • Pelvic pain

Contact your doctor right away if you experience:

  • A lump in your breast
  • Bone pain, increased thirst, constipation, or muscle weakness
  • Confusion, unusual behavior, or memory problems
  • Heart attack symptoms, such as chest pain or pressure, pain spreading to the jaw or shoulders, nausea, and sweating
  • Jaundice, characterized by yellowing of the skin or eyes
  • Stomach swelling or tenderness
  • Stroke symptoms, such as sudden numbness or weakness, sudden severe headache, slurred speech, vision or balance problems
  • Unusual pelvic pain or vaginal bleeding


When should I avoid using Premarin Vaginal Cream?

You should avoid using Premarin for treating menopause symptoms if you are experiencing vaginal bleeding, a bleeding disorder, or liver disease. Additionally, you should not use Premarin if you are scheduled for major surgery, if you have ever had a heart attack or stroke, and if you have a significant blood clot risk.

What are the risks of using Premarin Vaginal Cream?

Taking conjugated estrogens can increase your risk of heart attack, stroke, and blood clots. This risk may be compounded if you have diabetes, high cholesterol, or high blood pressure. Premarin Vaginal Cream may also compromise the strength of latex condoms, so other forms of birth control may be required.

Can boosting my intake of estrogen through Premarin prevent heart disease, stroke, or dementia?

No. Premarin cannot be used to prevent heart disease, stroke, or dementia because this medication may actually increase the risk of these conditions developing. Talk to your doctor for a more comprehensive list of the risks associated with Premarin Vaginal Cream. Always discuss the benefits and the potential risks with your doctor before starting a new treatment.

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A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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