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What is Prempro (conjugated estrogens and medroxyprogesterone)?

Prempro is a hormone medication used to treat symptoms of menopause, such as vaginal changes and hot flashes. Prempro may also be prescribed to prevent osteoporosis in menopausal women. The main ingredients in Prempro are conjugated estrogens and medroxyprogesterone. Estrogen is a female sex hormone produced by the ovaries and necessary for many essential bodily functions. Progesterone is another female hormone and is responsible for regulating ovulation and menstruation. The mixture in Prempro contains a form of progesterone, which can relieve vaginal dryness, burning, and irritation.

Always refer to the packaging instructions before using Prempro
Always completely follow your doctor’s directions.

  • Take Prempro at the same time each day
  • Monitor for vaginal bleeding
  • If prescribed, take progestin while using Prempro to mitigate the risk of uterine cancer
  • Attend doctor check-ups regularly
  • Examine for lumps on breasts


Prior to starting Prempro, make sure to tell your doctor if you have ever had:

  • Heart disease
  • Liver disease
  • Kidney disease
  • Gallbladder disease
  • A Hysterectomy
  • Asthma
  • Seizure disorders
  • Migraines
  • Lupus
  • Endometriosis
  • Angioedema
  • Porphyria
  • A thyroid disorder
  • High levels of blood calcium

You should not take Prempro if you have:

  • Unusual vaginal bleeding
  • Liver disease
  • A history of stroke, blood clot, or heart attack
  • An increased risk of blood clots
  • A history of hormone-related cancer, breast cancer, uterus cancer, cervix cancer, vaginal cancer

Using Prempro can increase your risk of blood clots, heart attack, and stroke. If you are already at risk because of high blood pressure, high cholesterol, obesity, or diabetes, Prempro can multiply your risk. You should also not take Prempro if you are pregnant, and tell your healthcare provider immediately if you become pregnant during treatment with Prempro.

Side Effects of Prempro

Common side effects of Prempro include:

  • Nausea
  • Gas
  • Stomach pain
  • Headache
  • Back pain
  • Depression and weakness
  • Breast pain
  • Itching, thinning scalp hair
  • Vaginal discharge
  • Changes in menstrual periods

Contact your doctor right away if you experience:

  • Heart attack symptoms, such as chest pain or pressure, pain spreading to the jaw or shoulders, nausea, and sweating
  • Stroke symptoms, such as sudden numbness or weakness, sudden severe headache, slurred speech, vision or balance problems
  • Stomach swelling or tenderness
  • Jaundice, characterized by yellowing of the skin or eyes
  • Confusion, unusual behavior, or memory problems
  • Unusual pelvic pain or vaginal bleeding
  • A lump in your breast
  • Bone pain, increased thirst, constipation, or muscle weakness


What drugs do I have to avoid when I am taking Prempro?

Many other drugs can interact with conjugated estrogens and medroxyprogesterone. It is always vital to inform your doctor of all the medications, vitamins, and herbal products you are taking before using Prempro. Prempro is known to interact with levothyroxine, esomeprazole, duloxetine, and vitamin D3. This list is far from a complete list of all Prempro drug interactions. If you are unsure if a certain drug will cause additional side effects when taken alongside Prempro, consult your doctor.

What happens if I miss a dose of Prempro?

If you miss a dose of Prempro, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next dose. Never take extra Prempro to make up for a missed dose.

Can I take Prempro while I am pregnant or breastfeeding?

You should not use Prempro if you are pregnant. This medication passes into breast milk and can reduce the quality of milk produced, so you should not use Prempro when you are breastfeeding. If you become pregnant during treatment with Prempro, speak with your healthcare provider right away.

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A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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