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What is Xigduo-XR (dapagliflozin/metformin)?

Xigduo-XR (dapagliflozin/metformin) is an oral diabetes medication that helps relieve symptoms by keeping blood sugar levels under control. “XR” indicates that this medication is an extended-release tablet. The first active ingredient in Xigduo-XR is dapagliflozin, which helps the kidneys remove glucose from the bloodstream.

The second active ingredient is metformin, which lowers glucose production in the liver and prevents the intestines from absorbing too much glucose. Xigduo-XR can be used alongside diet and exercise improvements to help control type 2 diabetes. This drug is not for treating type 1 diabetes.

Always read and understand the information on the drug packaging before using
Ensure that you follow all of your doctor’s instructions

  • This medication should be taken with food to avoid an upset stomach
  • Swallow the tablet whole. Do not chew, crush, or break this extended-release tablet
  • This drug may cause low blood sugar and subsequently, dizziness. Eat a fast-acting source of sugar to prevent hypoglycemia


Tell your doctor if you are allergic to metformin or dapagliflozin. Also, inform your doctor if you have any of the following conditions:

  • Severe kidney disease
  • If you are on dialysis
  • Metabolic acidosis
  • Diabetic ketoacidosis
  • Liver disease
  • Low blood pressure
  • A bladder infection
  • Urination problems
  • Pancreas problems
  • Eating a low-salt diet

Tell your healthcare provider immediately if you become pregnant. Do not use Xigduo-XR if you are pregnant.

Side Effects of Xigduo-XR

Common side effects include:

  • Genital infections
  • Stuffy nose
  • Sore throat
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Inform your doctor immediately if serious side effects occur, such as:

  • Little to no urination
  • Dehydration
  • Bladder infection
  • Ketoacidosis
  • Lactic acidosis


What are some drug interactions for Xigduo-XR I have to watch out for?

Non-steroidal anti-inflammatory drugs, such as aspirin, ibuprofen, naproxen, celecoxib, diclofenac, indomethacin, and meloxicam, may cause problems when taken in conjunction with Xigduo-XR. This medication should also not be taken with other oral diabetes medications or insulin. Digoxin, rifampin, and phenytoin are also known to interact with dapagliflozin and metformin. This list of possible drug interactions is not complete. Ask your doctor about the drugs you are taking, and always disclose all of your medications.

What is Xigduo-XR used for?

Xigduo-XR is an extended-release tablet used to treat and manage symptoms of type 2 diabetes. It contains dapagliflozin and metformin, which combine to remove glucose from the bloodstream and lower glucose production in the liver.

Is metformin extended-release a new diabetes medication?

Xigduo-XR (dapagliflozin/metformin) was approved by the FDA in 2014. Xigduo-XR is the first medication of its kind to be approved by the FDA. In this sense, this once-daily extended-release tablet is a relatively new diabetes medication used to treat type 2 diabetes.

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